THE EXECUTIVE DIRECTOR

Arthur E. Frankel, MD

Director, Cancer Center

Director, Division of Hematology/Oncology

Executive Director, Cancer Research Institute


Professor of Medicine at Texas A&M Health Science Center College of Medicine. Medical Degree from Harvard Medical School, 1973; Bachelor of Arts Harvard College, 1969.


Specialty training includes: Oncology Fellowship, Stanford University, 1982; Medicine Residency, Stanford University, 1980; Research Scientist, NIH, 1978; Medicine Internship, Yale University, New Haven, CT, 1974. Board certifications with American Board of Internal Medicine, Medical Oncology, Hematology.


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Liu, S., Wang, H., Currie, B.M., Molinolo, A., Leung, H.J., Moayeri, M., Basile, J.R., Alfano, R.W., Gutkind, J.S., Frankel, A.E., Bugge, T.H., Leppla, S.H.. Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature. J Biol Chem 2008; 283(1):529-40.

Alfano, R.W., Leppla, S.H., Liu, S., Bugge, T.H., Duesbery, N.S., Frankel, A.E., Potent inhibition of tumor angiogenesis by the matrix metalloproteinase-activated anthrax lethal toxin: implications for broad anti-tumor efficacy. Cell Cycle 2008; 7(6):745-9.

Alfano, R.W., Leppla, S.H., Liu, S., Bugge, T.H., Herlyn, M., Smalley, K.S., Bromberg-White, J.L., Duesbery, N.S., Frankel, A.E., Cytotoxicity of the matrix metalloproteinase-activated anthrax lethal toxin is dependent on gelatinase expression and B-RAF status in human melanoma cells. Mol Cancer Ther 2008; 7(5):1218-26.

Alfano, R.W., Leppla, S.H., Liu, S., Bugge, T., Meininger, C.J., Lairmore, T.C., Mulne, A.F., Davis, S.H., Duesbery, N.S., Frankel, A.E., Matrix metalloproteinase-activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formation during in vitro morphogenesis. In review.

Woo, J.H., Liu, J., Kang, S.H., Singh, R., Park, S.K., Su, Y., Ortiz, J., Neville Jr., D.M., Willingham, M.C. and Frankel, A. E., 2008. GMP production and characterization of the bivalent anti-human T cell immunotoxin, AdmDT390-bisFv(UCHT1) for phase I/II clinical trials. Protein Expr. Purif. 58(1):1-11.

Woo, J. H., Bour, S., Dang, T., Lee, Y., Park, S.K., Andreas, E., Kang, S. H., Liu, J., Neville Jr., D.M. and Frankel, A.E., 2008. Preclinical studies in rats and squirrel monkeys for safety evaluation of the bivalent anti-human T cell immunotoxin, A-dmDT390- bisFv(UCHT1). Cancer Immunol. Immunother. 57(8):1225-1239.

Awasthi, S., Singhal, S.S., Awasthi, Y.C., Martin, B., Awasthi, S., Woo, J.H., Cunningham, C.C. and Frankel, A.E., 2008. RLIP76 and cancer. Clin. Cancer Res. 14(14):4372-4377.

Su Y, Ortiz, J., Singh, R., Liu, S., Bugge, T.H., Leppla, S.H. and Frankel, A.E., 2006. Systematic urokinase-activated anthrax toxin therapy produces regressions of subcutaneous human non-small cell lung tumor in athymic nude mice. Cancer Research. 2007 April 67, 3329-3336.

Su,Y., Vanderlaag, K., Ireland, C., Ortiz, J., Grage, H., Safe, S. and Frankel, A.E., 2006. 1, 1-bis(3'- indolyl)-1-(p-biphenyl)methane inhibits basal-like breast cancer growth in athymic nude mice. Breast Cancer Res. 2007 Aug 31;9(4):R56 Epub.

Vanderlaag, K., Su,Y., Frankel, A.E., Grage, H., Smith R. 3rd, Khan, S., Safe, S. 1,1-Bis(3'-indolyl)-1 (psubstituted phenyl) methanes inhibit proliferation of estrogen receptornegative breast cancer cells by activation of multiple pathways. Breast Cancer Research and Treatment. 2007 Jul 12, Epub.

Woo, J.H., Liu, J. S., Kang, S.H., Singh, R., Park, S.K., Su, Y., Ortiz, J., Neville, D.M., Willingham, M.C., Frankel, A.E., GMP production and characterization of the bivalent antihuman T cell immunotoxin, AdmDT390- bisFv(UCHT1) for phase I/II clinical trials. Protein Expr Purif 2007; Nov 22, Epub.

Woo, J.H., Bour, S.H., Dang, T., Lee, Y.J., Park, S.K., Andreas, E., Kang, S.H., Liu, J.S., Neville, D.M., Frankel, A.E., Preclinical studies in rat and squirrel monkeys for safety evaluation of the bivalent anti-human T-cell immunotoxin, A-dmDT390-bisFv(UCHT1). Cancer Immunol Immunother 57: 1225-1239, 2008.

Kuo, S.R., Bour, S.H., Andreas, E.A., Park, S.K., Jackson, C., Duesbery, N., Leppla, S.H., Tang, W.J., Frankel, A.E., Anthrax toxin-induced shock in rats is associated with pulmonary edema and hemorrhage. Microbial Pathog 44: 467-472, 2008.

Frankel, A.E., Liu, J.S., Rizzieri, D.A. and Hogge, D.E. (2008) Phase I clinical study of diphtheria toxin-interleukin 3 fusion protein in patients with acute myeloid leukemia and myelodysplasia. Leukemia & Lymphoma 49:543-553